Effects of magnetic fields of up to 9.4 T on resolution and contrast of PET images as measured with an MR-BrainPET.

Simultaneous, hybrid MR-PET is expected to improve PET image resolution in the plane perpendicular to the static magnetic field of the scanner. Previous papers have reported this either by simulation or experiment with simple sources and detector arrangements. Here, we extend those studies using a realistic brain phantom in a recently installed MR-PET system comprising a 9.

Multi-Frame SPRITE: a method for resolution enhancement of multiple-point SPRITE data.

The Single Point Ramped Imaging with T1 Enhancement (SPRITE) sequence is well suited for the acquisition of magnetic resonance signals from fast relaxing nuclei and from heterogeneous materials. However, it is time inefficient compared to sequences that are based on frequency encoding because only one single point is acquired per excitation. Multiple-point SPRITE (mSPRITE) mitigates this problem with the acquisition of multiple FID points.

Multimodal imaging utilising integrated MR-PET for human brain tumour assessment.

Objectives: The development of integrated magnetic resonance (MR)-positron emission tomography (PET) hybrid imaging opens up new horizons for imaging in neuro-oncology. In cerebral gliomas the definition of tumour extent may be difficult to ascertain using standard MR imaging (MRI) only. The differentiation of post-therapeutic scar tissue, tumour rests and tumour recurrence is challenging.

Novel multisection design of anisotropic diffusion phantoms.

Diffusion-weighted magnetic resonance imaging provides access to fiber pathways and structural integrity in fibrous tissues such as white matter in the brain. In order to enable better access to the sensitivity of the diffusion indices to the underlying microstructure, it is important to develop artificial model systems that exhibit a well-known structure, on the one hand, but benefit from a reduced complexity on the other hand. In this work, we developed a novel multisection diffusion phantom made of polyethylene fibers tightly wound on an acrylic support.

Non-Gaussian diffusion in human brain tissue at high b-factors as examined by a combined diffusion kurtosis and biexponential diffusion tensor analysis.

Diffusion tensor imaging (DTI) permits non-invasive probing of tissue microstructure and provides invaluable information in brain diagnostics. Our aim was to examine approaches capable of capturing more detailed information on the propagation mechanisms and underlying tissue microstructure in comparison to the conventional methods. In this work, we report a detailed in vivo diffusion study of the human brain in an extended range of the b-factors (up to 7000 s mm(-2)) performed on a group of 14 healthy volunteers at 3T.