Publications by authors named "J Kaes"
RATIONALE+OBJECTIVE/ Cystic fibrosis (CF) is characterized by bronchiectasis on imaging, while functionally evolving towards obstructive impairment. Despite its assumed importance in CF, small airway remodeling and its relation to bronchiectasis, is still poorly understood. METHOD/ On high-resolution computed tomography (HRCT, 600µm, CF=21, control=6) and micro-computed tomography (µCT, 150µm, CF=3, control=1) scans of inflated explant lungs, AV% (airway/total lung volume) was calculated as marker for bronchiectasis, while airway segmentation was used for generation analysis.
View Article and Find Full Text PDFElevated neutrophil counts in broncho-alveolar lavage (BAL) fluids of lung transplant (LTx) patients with chronic lung allograft dysfunction (CLAD) are associated with disease pathology. However, phenotypical characteristics of these cells remained largely unknown. Moreover, despite enhanced levels of the most potent human neutrophil-attracting chemokine CXCL8 in BAL fluid, no discrimination had been made between natural NH-terminally truncated CXCL8 proteoforms, which exhibit up to 30-fold differences in biological activity.
View Article and Find Full Text PDFLung transplantation is still hindered by a high rate of chronic rejection necessitating profound immunosuppression with its associated complications. Donor-specific blood transfusion is a pre-transplant strategy aimed at improving graft acceptance. In contrast with standard stored blood or donor-specific regulatory T cells transfusions, this approach utilizes fresh whole blood from the donor prior to allograft transplantation, encompassing all cell types and plasma.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on chronic rejection in lung transplantation, exploring its nature, timing, and location, challenging the idea that it primarily affects airways.
- - Researchers conducted experiments on mice, sacrificing them at different time points post-transplantation to analyze the progression of chronic rejection through histology and advanced imaging techniques.
- - Findings revealed that chronic rejection begins with innate inflammation around small arteries and evolves through various stages, ultimately affecting bronchioles, suggesting that the process may not align with current beliefs about Chronic Lung Allograft Dysfunction (CLAD).
Article Synopsis
- Chronic lung allograft dysfunction (CLAD) has three main types: bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS), and a mixed type combining both.
- A study looked at how the structure of airways changes in these types and found that BOS and mixed cases had more blockage in the larger airways compared to RAS, which had problems lower down in the smaller airways.
- These blockages were mostly caused by inflammation and scarring, leading to problems with breathing in all CLAD types.