Publications by authors named "J Kabalimoorthy"
Article Synopsis
- The study investigated the potential of troxerutin as a chemopreventive agent against colon cancer induced by 1,2-dimethylhydrazine (DMH) in rats.
- Rats were divided into six groups, with some receiving DMH and others receiving varying doses of troxerutin alongside DMH for 16 weeks.
- Results indicated that troxerutin, particularly at 25 mg/kg body weight, significantly improved antioxidant levels and colon health, suggesting it could be an effective agent for colon cancer prevention.
Objectives: The present study has aimed to evaluate chemopreventive potential of d-carvone on oxidative stress markers, biotransforming enzymes, incidence of colonic polyps and aberrant crypt foci (ACF) in 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis.
Materials And Methods: Rats were randomly divided into six groups, with group I serving as control. Group II animals received d-carvone every day orally (20 mg/kg body weight) for 16 weeks; groups III-VI received subcutaneous injections of DMH (20 mg/kg body weight) once a week, for the first 4 weeks.
Objectives: To evaluate the extent of lipid peroxidation and the antioxidant levels in breast cancer patients in relation to different clinical stages and menopausal status.
Design And Methods: Fifty newly diagnosed women with adenocarcinoma of the breast were divided into different groups based on clinical staging and menopausal status. The extent of lipid peroxidation as reflected by the formation of thiobarbituric acid-reactive substances (TBARS), lipid hydroperoxides (LOOH), and conjugated dienes (CD) as well as the status of the antioxidants superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (GPx) in tumor tissues and adjacent normal tissues were estimated in these patients.
Objectives: To correlate the extent of lipid peroxidation with the antioxidant status in the circulation of patients with fibroadenoma and adenocarcinoma of the breast.
Design And Methods: Ten fibroadenoma and thirty breast cancer patients and an equal number of age- and sex- matched normal subjects were chosen for the study. Lipid peroxidation as evidenced by thiobarbituric acid reactive substances (TBARS) and the status of the antioxidants superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) ascorbic acid and vitamin E were estimated.