[Transcription factor ChREBP – the coordinator of carbohydrate and lipid metabolism].

Transcription factor ChREBP, in complex with MLX, binds to carbohydrate-response element (ChoRE) located in the promoters of genes related to glycolysis, gluconeogenesis, pentosephosphate pathway and lipogenesis, activating their transcription following stimulation with glucose, insulin-independently. In this article the mechanisms of ChREBP regulation and ChREBP functions under both physiological and pathophysiological conditions are described in detail. The possible use of ChREBP activity modulation as a therapeutic tool, e.

High-frequency intracellular infection and erythrogenic toxin A expression undergo phase variation in M1 group A streptococci.

A clonal variant of serotype M1 group A streptococcus, strain 90-131, disseminated to several continents, where it was associated with severe systemic infections and toxic shock. Although this strain harbours the speA gene and is efficiently internalized by human epithelial cells, clinical isolates often fail to express the erythrogenic toxin under laboratory growth conditions. Cultures of strain 90-131 were observed to phase vary between small, dry, compact and larger, more mucoid colonies.

Computerized Clinical Simulation Testing. A new look for the NCLEX-RN examination?

Computerized Clinical Simulation Testing (CST) is under research and development by the National Council of State Boards of Nursing for potential use as a component of the National Council Licensure Examination for Registered Nurses. It is designed to evaluate the application of the clinical decision-making process to the management of client care. The authors describe how CST works, the case development and scoring key development processes, and the plans for the CST pilot study scheduled for spring 1998.

The development of automated client responses for computerized clinical simulation testing.

Computerized Clinical simulation Testing (CST) is under research and development by the National Council of State Boards of Nursing for potential use as a component of the National Council Licensure Examination for Registered Nurses. This interactive software permits the realistic assessment and management of client needs through free-text entry of requests for nursing activities. Implementation of each nursing activity elicits a realistic client response.

Building a nursing activity database for processing free-text entry during computerized clinical simulation testing.

Computerized Clinical Simulation Testing is under research and development by the National Council of State Boards of Nursing for potential use as a component of the National Council Licensure Examination for Registered Nurses. This interactive software permits the realistic assessment and management of client needs through free-text entry of requests for nursing activities, each of which elicit a response from the client. The efficiency and accuracy of system recognition of the free-text requests depends on the careful structuring of a comprehensive nursing activity database.