Sex-linked, androgen-dependent differences in renal retention of trimethylselenonium ions.

The metabolism of trimethylselenonium ions (TMSe) was studied in male and female rats during maturation. Selenium (Se) retention in the whole body as well as in organs was found to be significantly higher in male rats than in female a few hours after parenteral administration of TMSe. The pronounced Se accumulation was observed in male kidneys.

Comparison of the kinetics of a trace and a sublethal dose of selenite in rats, with particular attention being given to blood selenium distribution.

The male rats were injected i.p. with a trace or a sublethal dose of [75Se]selenite (0.

Dose-dependent distribution of injected selenium in rat blood. Effect of previous selenium intake in drinking water.

The effect of an administered dose of 75Se-selenite and a previously increased selenium intake in drinking water (0.1 mg/l) on the distribution of injected selenium in rat blood was studied. In a dose range of 0.

Protection against selenite toxicity by previous administration of selenium compounds.

2-month-old male rats kept on a standard laboratory diet containing 0.06 microgram Se/g dry weight were found to be more sensitive to the toxic action of selenite than female rats of corresponding age. This sex-dependent difference was not found in 20-day-old animals.