Vulnerable self-disclosure co-develops in adolescent friendships: Developmental foundations of emotional intimacy.

This study examines the development of vulnerable self-disclosure in supportive interactions from ages 13 to 29. A diverse community sample (N = 184; 85 boys 99 girls; 58% white, 29% Black, 13% other identity groups) participated in annual observed interactions with close friends and romantic partners. Participants were observed as they sought and provided support to their best friends each year from age 13 to 18, and as they sought support from their romantic partners from age 19 to 29.

Significant Radiation Reduction Using Cloud-Based AI Imaging in Manually Matched Cohort of Complex Aneurysm Repair.

Objective: Cloud-based, surgical augmented intelligence (Cydar Medical, Cambridge, UK) can be used for surgical planning and intraoperative imaging guidance during complex endovascular aortic procedures. We aim to evaluate radiation exposure, operative safety metrics, and post-operative renal outcomes following implementation of Cydar imaging guidance using a manually matched cohort of aortic procedures.

Methods: We retrospectively reviewed our prospectively maintained database of endovascular aortic cases.

Xenotransplantation: future frontiers and challenges.

Purpose Of Review: Recent advancements in genetic engineering have propelled the field of xenotransplantation from preclinical models to early compassionate use cases. As first-in-human clinical trials (FIHCTs) approach, we examine recent developments, ethical and regulatory challenges, immunological considerations, and the clinical infrastructure necessary for successful xenotransplantation trials.

Recent Findings: Expanded access transplants of pig hearts, kidneys, and livers have identified key challenges.

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.

Interoception broadly refers to awareness of one's internal milieu. Although the importance of the body-to-brain communication that underlies interoception is implicit, the vagal afferent signalling and corresponding brain circuits that shape perception of the viscera are not entirely clear. Here, we use mice to parse neural circuits subserving interoception of the heart and gut.

Patterns in affect and personality states across the menstrual cycle.

Affective, behavioral, and cognitive (i.e., personality) states fluctuate across situations and context, yet the biological mechanisms regulating them remain unclear.