Publications by authors named "J K Sohng"
The Streptomyces sp. is considered the vast reservoir of bioactive natural products belonging to different classes like polyketides, terpenoids, lanthipeptides, and non-ribosomal peptides to name a few. The ubiquitous distribution of the genus makes them capable of producing distinct compounds.
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- The study focuses on identifying specialized metabolites from microorganisms that could help in cancer treatment and combat multidrug-resistant pathogens, specifically through the analysis of naphthoquinones and their derivatives.
- Researchers discovered new furanonaphthoquinones (fnqs) with promising anticancer properties from the microorganism sp. CS682, showing lower toxicity compared to traditional naphthoquinones.
- The study utilized techniques like genome mining and CRISPR-Cas9 for gene editing, leading to the isolation and characterization of two compounds, NOC-IBR1 and NOC-IBR2, with NOC-IBR2 demonstrating greater biological activity through various assays.
are well-known for producing bioactive secondary metabolites, with numerous antimicrobials essential to fight against infectious diseases. Globally, multidrug-resistant (MDR) microorganisms significantly challenge human and veterinary diseases. To tackle this issue, there is an urgent need for alternative antimicrobials.
View Article and Find Full Text PDFBiosynthesis of Apigenin Glucosides in Engineered .
J Microbiol Biotechnol
May 2024
Glucosylation is a well-known approach to improve the solubility, pharmacological, and biological properties of flavonoids, making flavonoid glucosides a target for large-scale biosynthesis. However, the low yield of products coupled with the requirement of expensive UDP-sugars limits the application of enzymatic systems for large-scale. is a Gram-positive and generally regarded as safe (GRAS) bacteria frequently employed for the large-scale production of amino acids and bio-fuels.
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