Basic Science and Pathogenesis.

Background: Obesity and ageing individually pose significant challenges to global public health, leading to preventable deaths. With an increasing geriatric population due to improved medical interventions, the intersection of these health issues becomes a critical concern worldwide. Both developed and developing countries grapple with the consequences of obesity, a major risk factor for various conditions like cardiovascular diseases, hypertension, type 2 diabetes, dementia, and neuropsychiatric diseases.

Basic Science and Pathogenesis.

Background: Obesity is caused by the buildup of excess body fat, which upsets homeostasis. Genetic, epigenetic, and behavioural variables all have a role in the pathophysiology of obesity. In turn, obesity throws off the sleep cycle, leading to sleep problems.

The Enigma of Idiopathic Multicentric Castleman Disease: An Elusive Diagnosis.

Castleman disease (CD) is a rare lymphoproliferative disorder encompassing a spectrum of conditions with distinct histopathological findings and varied clinical presentations. Diagnostic challenges are often encountered due to overlapping features with other malignancies, infections, and autoimmune disorders. Idiopathic multicentric Castleman disease (iMCD) is a subtype of CD, characterized by generalized lymphadenopathy, polyclonal lymphoproliferation, systemic inflammation, and a cytokine storm that can be life-threatening.

From Envelope Spectra to Bearing Remaining Useful Life: An Intelligent Vibration-Based Prediction Model with Quantified Uncertainty.

Bearings are pivotal components of rotating machines where any defects could propagate and trigger systematic failures. Once faults are detected, accurately predicting remaining useful life (RUL) is essential for optimizing predictive maintenance. Although data-driven methods demonstrate promising performance in direct RUL prediction, their robustness and practicability need further improvement regarding physical interpretation and uncertainty quantification.

Sleep and Immune System Crosstalk: Implications for Inflammatory Homeostasis and Disease Pathogenesis.

Background: Sleep and immune function are interconnected aspects of health that mutually impact each other in disease development and inflammatory homeostasis. Different aspects of immunology are regulated by different sleep characteristics, impacting on specific aspects of immune function including cytokine production and T-cell activity. Ongoing disruptions of sleep have been linked to heightened inflammation and are suspected in the pathogenesis and disease course of a range of life-style-related illnesses, including diabetes and neurodegenerative diseases.