Publications by authors named "J K Rone"
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe an innate immune metabolic switch that programs long-term intestinal tolerance.
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- Gut inflammation involves both immune and non-immune cells, with their interactions influenced by the gut's structure and changes during inflammation.
- Researchers used a technique called MERFISH to analyze 1.35 million cells in a mouse model of colitis, identifying various cell types and their roles in inflammation.
- They discovered different tissue areas associated with inflammation, characterized by specific fibroblast types, and found that similar cellular patterns exist in human ulcerative colitis, offering insights into gut remodeling during inflammation.
Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis. However, little is known about the stability of these astrocyte subsets and their ability to integrate past stimulation events. Here we report the identification of an epigenetically controlled memory astrocyte subset that exhibits exacerbated pro-inflammatory responses upon rechallenge.
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- - Researchers are facing challenges in creating effective treatments for metastatic brain cancer due to a lack of experimental systems that mimic the conditions of the brain tumor environment.
- - A study by Ishibashi et al. has introduced a new co-culture system that combines glial cells and cancer cells to better understand brain metastasis.
- - Their findings reveal a specific mechanism driven by astrocytes that can potentially be targeted for improving brain cancer treatments.