Publications by authors named "J K Radder"
Article Synopsis
- Critical illness alters the human microbiome, affecting the oral, lung, and gut bacteria in mechanically ventilated patients, leading to reduced microbial diversity and increased pathogens.
- Advanced DNA sequencing methods were used to analyze the microbiota of 479 patients, revealing that clinical factors like COPD, immunosuppression, and antibiotic use influence the patterns of dysbiosis.
- Lung microbiota diversity and composition were found to predict patient survival better than traditional clinical predictors, suggesting the potential for using microbiome analysis as a tool for improving patient outcomes in critical care settings.
Purpose: We examined magnetic field dependent SNR gains and ability to capture them with multichannel receive arrays for human head imaging in going from 7 T, the most commonly used ultrahigh magnetic field (UHF) platform at the present, to 10.5 T, which represents the emerging new frontier of >10 T in UHFs.
Methods: Electromagnetic (EM) models of 31-channel and 63-channel multichannel arrays built for 10.
Acute inflammation is heterogeneous in critical illness and predictive of outcome. We hypothesized that genetic variability in novel, yet common, gene variants contributes to this heterogeneity and could stratify patient outcomes. We searched algorithmically for significant differences in systemic inflammatory mediators associated with any of 551,839 SNPs in one derivation (n = 380 patients with blunt trauma) and two validation (n = 75 trauma and n = 537 non-trauma patients) cohorts.
View Article and Find Full Text PDFRespiratory microbial dysbiosis is associated with acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) in critically ill patients. However, we lack reproducible respiratory microbiome signatures that can increase our understanding of these conditions and potential treatments. Here, we analyze 16S rRNA sequencing data from 2,177 respiratory samples collected from 1,029 critically ill patients (21.
View Article and Find Full Text PDFArticle Synopsis
- Critical illness alters the microbiome in the oral, lung, and gut areas, leading to significant changes like decreased diversity and increased harmful bacteria.
- A study of 479 patients on mechanical ventilation revealed that factors like chronic obstructive pulmonary disease and antibiotic use influence these changes.
- Lung microbiota diversity was found to independently predict patient survival, suggesting it could be useful for guiding treatment in critically ill individuals and indicating the potential for targeted microbiome therapies.