Publications by authors named "J K R Boult"
Article Synopsis
- KORTUC, a treatment combining hydrogen peroxide and sodium hyaluronate, shows promise in reducing hypoxic conditions in tumors after being injected directly into them, potentially improving cancer treatment outcomes.
- In tests using human tumor models, KORTUC led to a notable decrease in hypoxia markers and increased reactive oxygen species levels, indicating enhanced oxygen availability in cancerous tissues.
- If successful in ongoing clinical trials, KORTUC could transform radiation therapy for various cancers, particularly those where low oxygen levels limit treatment effectiveness.
Purpose: Inspired by a preliminary survey of the Scholarship of Teaching and Learning (SoTL) literature conducted by Friberg et al. (2014), the current study aimed to expand the original study's findings-that SoTL was rarely published in the communication sciences and disorders (CSD) literature from 2009 to 2013-to the subsequent 8-year period (2014-2021). The latter period was of particular relevance considering the dissolution of one American Speech-Language-Hearing Association (ASHA)-affiliated publication and the addition of another non-ASHA-affiliated publication during that time.
View Article and Find Full Text PDFHyaluronan (HA) is a key component of the dense extracellular matrix in breast cancer, and its accumulation is associated with poor prognosis and metastasis. Pegvorhyaluronidase alfa (PEGPH20) enzymatically degrades HA and can enhance drug delivery and treatment response in preclinical tumour models. Clinical development of stromal-targeted therapies would be accelerated by imaging biomarkers that inform on therapeutic efficacy in vivo.
View Article and Find Full Text PDFArticle Synopsis
- Scientists are studying a new treatment for a type of brain tumor called glioblastoma (GBM) that helps patients live longer but often comes back after treatment.
- They combined a special light therapy with a molecule called Z-IR700, which targets the tumor and helps activate the immune system against it.
- The results showed that this treatment not only helps doctors see the tumor better but also destroys tumor cells and makes the body’s immune system stronger against the cancer.