Publications by authors named "J K Pittaway"
Disruption of processes involved in tissue development and homeostatic self-renewal is increasingly implicated in cancer initiation, progression, and recurrence. The adrenal cortex is a dynamic tissue that undergoes life-long turnover. Here, using genetic fate mapping and murine adrenocortical carcinoma (ACC) models, we have identified a population of adrenocortical stem cells that express delta-like non-canonical Notch ligand 1 (DLK1).
View Article and Find Full Text PDFInternational guidelines recommend local therapies (LTs) such as local thermal ablation (LTA; radiofrequency, microwave, cryoablation), transarterial (chemo)embolisation (TA(C)E), and transarterial radioembolisation (TARE) as therapeutic options for advanced adrenocortical carcinoma (ACC). However, the evidence for these recommendations is scarce. We retrospectively analysed patients receiving LTs for advanced ACC.
View Article and Find Full Text PDFArticle Synopsis
- Adrenocortical carcinomas (ACCs) are aggressive tumors that can worsen patient outcomes, especially when linked to changes in a key enzyme called SGPL1, which is involved in lipid metabolism.
- Research showed that higher SGPL1 levels correlated with decreased patient survival and that manipulating SGPL1 expression in lab cells affected their growth and survival rates.
- The study concluded that ACC tumors overexpressing SGPL1 thrive on metabolic resources, enhancing their growth and invasiveness, which likely contributes to poorer patient outcomes.
Background: International guidelines emphasise the role of radiotherapy (RT) for the management of advanced adrenocortical carcinoma (ACC). However, the evidence for this recommendation is very low.
Methods: We retrospectively analysed all patients who received RT for advanced ACC in five European centres since 2000.