Publications by authors named "J K Patra"

Aging is a complex process that involves many physiological mechanisms that gradually impair normal cellular and tissue function and make us more susceptible to diseases and death. It is influenced by intrinsic factors like cellular function and extrinsic factors like pollution and UV radiation. Recent scientific studies show that traditional plant-based foods and supplements can help mitigate the effects of aging.

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Artemisinin is a truly fascinating drug in many ways. Since the unrestrained procedure of its detection, as an antimalarial drug, artemisinin has received a great deal of consideration. Recently, application of artemisinin-based combination therapy has been broadly applied for treating numerous ailments.

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Background: Bio-based synthesis of metallic nanoparticles has garnered much attention in recent times owing to their non-toxic, environmentally friendly, and cost-effective nature.

Methods: In this study, gold nanoparticles (S4-GoNPs) were synthesized by a simple and environmentally friendly technique using an aqueous extract of jamun leaves (JLE) as an effective capping, stabilizer, and reducing agent. JLE was screened for the presence of phytochemicals followed by synthesis, characterization, and evaluation of their antibacterial, antidiabetic, antioxidant, and photocatalytic degradation potentials using standard established procedures.

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Article Synopsis
  • The study investigates dual inhibitors of falcipains FP-2 and FP-3, which show potential toxicity due to similar binding affinities with human cathepsins.
  • Researchers aim to enhance the selectivity of these inhibitors by designing new analogs that interact better with falcipains and less with human cathepsins.
  • Molecular dynamics simulations reveal that the newly designed analogs exhibit improved binding affinities and selectivity towards falcipains, reducing the risk of toxicity.
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In the realm of organic synthesis, direct C-H alkynylation with arylacetylenes has remained a daunting challenge due to competing annulations or alkenylation. Addressing this long-standing issue, herein we demonstrate the merging of copper and photocatalysis to achieve the elusive C-H alkynylation of benzamides using arylacetylenes or arylpropiolic acids. Unlike conventional copper-mediated C-H activations, our protocol circumvents the need for high temperatures and stoichiometric amounts of copper salts or metal/non-metal oxidants.

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