Publications by authors named "J K Parks"
Background: The use of emergency tourniquets among military personnel has helped to dramatically reduce battlefield deaths and has recently gained popularity in the civilian sector. Yet, even well-trained individuals can find it difficult to assess proper tourniquet application. Emergency tourniquets are typically deemed sufficiently tightened through cursory visual confirmation or pulse assessment.
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- - The study investigated a diverse group of 95 enzymes from the N-terminal nucleophile hydrolase superfamily, focusing on their ability to hydrolyze synthetic polyamides like nylon.
- - About 40% of these enzymes demonstrated significant nylon hydrolase activity, comparable to the well-known enzyme NylC, without any clear link between their evolutionary relationships and their hydrolytic capabilities.
- - Researchers identified several enzymes with strong substrate selectivity, especially those that efficiently processed Nylon 6,6, and also analyzed the crystal structure of a specific hydrolase to better understand the factors affecting its activity and selectivity.
Mercury (Hg) is a heavy metal that exhibits high biological toxicity. Monomethylmercury and dimethylmercury are neurotoxins and a significant environmental concern as they bioaccumulate and biomagnify within the aquatic food web. Microbial Hg methylation involves two proteins, HgcA and HgcB.
View Article and Find Full Text PDFBryant-Li-Bhoj syndrome (BLBS) is associated with germline mutations in the genes encoding human histone H3.3. While to date 70 H3.
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- The standard treatment for metastatic prostate cancer involves drugs that target androgen receptor (AR) signaling, but resistance to these treatments is common.
- Research shows that the AR inhibitor enzalutamide causes DNA replication stress in AR-positive prostate cancer cells, leading to increased DNA damage.
- Combining enzalutamide with a translesion DNA synthesis (TLS) inhibitor, JH-RE-06, enhances the sensitivity of these cancer cells to treatment and significantly reduces tumor growth in a mouse model.