Under-representation for Female Pelvis Cancers in Commercial Auto-segmentation Solutions and Open-source Imaging Datasets.

Aim: Artificial intelligence (AI) based auto-segmentation aids radiation therapy (RT) workflows and is being adopted in clinical environments facilitated by the increased availability of commercial solutions for organs at risk (OARs). In addition, open-source imaging datasets support training for new auto-segmentation algorithms. Here, we studied if the female and male anatomies are equally represented among these solutions.

Impact of Lower-Volume Training on Physical Fitness Adaptations in Team Sports Players: A Systematic Review and Meta-analysis.

Background: A small number of reviews have explored lower- versus higher-volume training in non-athletes, but the growing challenge of congested schedules in team sports highlights the need to synthesize evidence specific to team sport athletes. Thus, the objectives of this systematic review with meta-analysis are twofold: (i) to summarize the primary physiological and physical fitness outcomes of lower-volume versus higher-volume training interventions in team sports players; and (ii) to compare the effects of lower-volume training with higher, considering the training modalities used.

Methods: We conducted searches across key databases, including PubMed, Scopus, SPORTDiscus, and Web of Science.

Rates of Return to Sexual Activity Are High In Patients Undergoing Hip Arthroscopy And Occurs Within Six Weeks Postoperatively In Most Patients: A Systematic Review.

Purpose: To provide an aggregate review of literature on 1) outcomes related to the quality of intercourse (frequency, postoperative pain during intercourse, postoperative sexual dysfunction) after hip arthroscopy and 2) patient-reported outcomes regarding postoperative sexual function after hip arthroscopy.

Methods: This systematic review followed The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. PubMed, Cochrane Controlled Register of Trials (CENTRAL), and Scopus were queried in March 2024.

TDP43 autoregulation gives rise to dominant negative isoforms that are tightly controlled by transcriptional and post-translational mechanisms.

The nuclear RNA-binding protein TDP43 is integrally involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Previous studies uncovered N-terminal TDP43 isoforms that are predominantly cytosolic in localization, prone to aggregation, and enriched in susceptible spinal motor neurons. In healthy cells, however, these shortened (s)TDP43 isoforms are difficult to detect in comparison to full-length (fl)TDP43, raising questions regarding their origin and selective regulation.

Continuous glucose monitoring among adults with type 2 diabetes receiving noninsulin or basal insulin therapy in primary care.

Rates of type 2 diabetes (T2D) continue to rise in the United States, with many patients failing to achieve glycemic targets. Primary care providers often serve as the sole clinician managing diabetes. Continuous glucose monitors (CGMs) have shown promise in diabetes management, yet their adoption in primary care settings, especially among patients with T2D not using intensive insulin therapy, remains limited.