Acute cardiovascular effects of insulin in hyperglycaemic type I diabetics.

Cardiovascular responses to high-dose (0.100 IE kg-1 h-1) and low-dose insulin infusion (0.005-0.

Influence of short term verapamil treatment on glucose metabolism in patients with non-insulin dependent diabetes mellitus.

The effect of a sustained-release verapamil preparation on glucose metabolism was investigated in 10 patients with non-insulin dependent diabetes mellitus. In a single blind cross-over study verapamil 240 mg b.d.

Short time effects of growth hormone on glucose metabolism and insulin and glucagon secretion in normal man.

The present study was undertaken in order to evaluate the acute metabolic and hormonal effects of human growth hormone in healthy subjects. Glucose turnover, plasma glucose, FFA, insulin, C-peptide, glucagon, and somatostatin concentrations were determined in the fasting state after a bolus injection of placebo or growth hormone in quantities producing increases in plasma growth hormone levels within the normal physiological range. We found that growth hormone administration resulted in negligible changes in plasma glucose, no significant changes in appearance or disappearance rates of glucose, a moderate increase in FFA and a moderate fall in plasma insulin, C-peptide and glucagon concentrations, while plasma somatostatin levels were unchanged.