Publications by authors named "J K Kulski"
SINE-VNTR-Alu (SVA) retrotransposons can regulate expression quantitative trait loci (eQTL) of coding and noncoding genes including transposable elements (TEs) distributed throughout the human genome. Previously, we reported that expressed SVAs and human leucocyte antigen (HLA) class II genotypes on chromosome 6 were associated significantly with Parkinson's disease (PD). Here, our aim was to follow-up our previous study and evaluate the SVA associations and their regulatory effects on the transcription of TEs within the HLA class II genomic region.
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- - Immune-related drug delivery systems (DDSs) in humanized mouse models are crucial for bridging cancer research between preclinical and clinical stages, allowing for a better understanding of therapies and their interactions with human cells and the immune system.
- - The focus is on a recently developed DDS that utilizes a novel mouse model known as PBL-NOG-hIL-4-Tg, which allows for rapid reconstruction of individual donor immunity while minimizing complications like graft-versus-host disease.
- - This DDS has a dual role: it not only targets cancer cells but also modulates the immune response, which could enhance cancer treatments significantly by improving our knowledge of immune reactions.
Previously, we found that a greater dissimilarity in swine leukocyte antigen () class I and class II alleles between mating partners resulted in increased farrowing rates in a highly inbred population of Microminipigs (MMPs). In this follow-up study, we have analyzed the effects of dissimilarity in alleles between mating partners for seven different reproductive traits, including litter size and the number of stillborn and live or dead weaned piglets. We determined the relationships among reproductive traits within each mating event and the amino acid distances of alleles as markers of diversity between mating partners.
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- * Currently, about 20% of the combined haplotypes from Europe are represented, but many common and rare haplotypes, particularly those associated with certain diseases, are still lacking from the global sample.
- * The workshop is now seeking DNA samples from diverse populations, especially non-Europeans, resulting in 537 individuals contributing 294 distinct haplotypes, but still highlighting the need for more representation, particularly from African populations.
Introduction: Parkinson's disease (PD) is a neurodegenerative and polygenic disorder characterised by the progressive loss of neural dopamine and onset of movement disorders. We previously described eight SINE-VNTR-Alu (SVA) retrotransposon-insertion-polymorphisms (RIPs) located and expressed within the Human Leucocyte Antigen (HLA) genomic region of chromosome 6 that modulate the differential co-expression of 71 different genes including the HLA classical class I and class II genes in a Parkinson's Progression Markers Initiative (PPMI) cohort.
Aims And Methods: In the present study, we (1) reanalysed the PPMI genomic and transcriptomic sequencing data obtained from whole blood of 1521 individuals (867 cases and 654 controls) to infer the genotypes of the transcripts expressed by eight classical HLA class I and class II genes as well as and the haplotypes, and (2) examined the statistical differences between three different PD subgroups (cases) and healthy controls (HC) for the HLA and SVA transcribed genotypes and inferred haplotypes.