Publications by authors named "J K Kiwanuka"

Article Synopsis
  • - Uganda is experiencing a rising incidence of colorectal cancer (CRC), primarily affecting younger patients who often present with advanced-stage disease, highlighting a lack of genetic research in this area.
  • - In a study involving 127 Ugandan CRC patients, next-generation sequencing revealed 48 mutations in the APC gene, with 9 being novel and pathogenic, along with additional variants in PIK3CA and SMAD4 genes that could significantly impact treatment strategies.
  • - The research offers valuable clinicopathological data and insights into genetic variations of CRC, contributing to a greater understanding of how Ugandan CRC cases differ from those in other populations.
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Introduction: Low-income countries in East Africa have a lower incidence of colorectal cancer (CRC) than high-income countries; however, the incidence has steadily increased in the last few decades. In Uganda, the extent to which genetic and environmental factors, particularly dietary factors, contribute to the aetiology of CRC is unclear. Therefore, the objective of our study was to determine the relationship between dietary factors and CRC in Uganda.

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The global spread of antimicrobial resistance (AMR) poses an increasing challenge for clinicians in Uganda, where microbiological diagnostics are not routinely available or accessible. The aim of this study was to determine pathogen prevalence and antibiotic resistance patterns in patients with wound infections following trauma at a national referral hospital in Kampala, Uganda. In addition, the suitability of currently used empirical treatment options in this setting was evaluated.

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Introduction: In Western countries, right-sided colon cancers (RSCC) present at an older age and advanced stage. Researchers believe that there is a difference between left-sided colon cancer (LSCC) and RSCC. In Uganda, however, it is unknown whether differences exist in the pathological profile between RSCC and LSCC.

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Background: Paenibacillus thiaminolyticus is a cause of postinfectious hydrocephalus among Ugandan infants. To determine whether Paenibacillus spp is a pathogen in neonatal sepsis, meningitis, and postinfectious hydrocephalus, we aimed to complete three separate studies of Ugandan infants. The first study was on peripartum prevalence of Paenibacillus in mother-newborn pairs.

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