Publications by authors named "J K Izes"
Article Synopsis
- The study explores the suitability of the TriNetX database for researching the real-world management of Von Hippel-Lindau (vHL), a rare hereditary disease characterized by various tumors.
- The researchers analyzed data from 1,232 patients diagnosed with vHL within the TriNetX database to identify the prevalence of several vHL-related conditions, finding that certain conditions like renal cell carcinoma and pheochromocytomas were more common than others.
- Despite the robust patient data available, the findings suggest that vHL and its associated conditions may be underdiagnosed within the TriNetX database, casting doubt on its effectiveness for comprehensive vHL studies compared to existing literature.
Article Synopsis
- Brain metastasis from prostate adenocarcinoma (PCa) is uncommon but often leads to a poor prognosis, necessitating an assessment of its clinical and histopathological features for better diagnosis.
- A study reviewed 21 cases from the past 20 years, discovering that the average age for brain metastasis presentation was 70, with diverse types and locations of lesions.
- The research highlighted various histological patterns in tumor cells, including cribriform and papillary structures, and noted that nearly half of the cases displayed necrosis, indicating the need for thorough evaluation to improve diagnostic accuracy.
Emphysematous pyelonephritis (EPN) is a severe, acute necrotizing infection of the kidney with gas accumulation in the renal parenchyma, collecting ducts, and/or perirenal tissue. We report a case of EPN in a 66 year-old male with uncontrolled diabetes mellitus (DM), urinary tract infection and septic shock necessitating emergent bilateral radical nephrectomy. Morphologically, the kidney parenchyma revealed severe acute bacterial pyelonephritis with extensive abscesses, gas cysts, necrosis and foci of infarctions.
View Article and Find Full Text PDFCase report: Bilateral emphysematous pyelonephritis with pneumatosis intestinalis.
Urol Case Rep
January 2022
Emphysematous pyelonephritis is a severe and rare gas producing infection in the renal parenchyma or collecting system. Diabetes mellitus is an established risk factor. Treatment options include antibiotics, minimally invasive management such as percutaneous drainage, or nephrectomy.
View Article and Find Full Text PDFPurpose: Germline testing (GT) for prostate cancer (PCA) is now central to treatment and hereditary cancer assessment. With rising demand for and shortage of genetic counseling (GC), tools to deliver pretest informed consent across practice settings are needed to improve access to GT and precision care. Here, we report on Evaluation and Management for Prostate Oncology, Wellness, and Risk (EMPOWER), a patient-choice study for pretest video-based genetic education (VBGE) versus GC to inform urgent practice needs.
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