Publications by authors named "J K House"

Achieving net zero global emissions of carbon dioxide (CO), with declining emissions of other greenhouse gases, is widely expected to halt global warming. CO emissions will continue to drive warming until fully balanced by active anthropogenic CO removals. For practical reasons, however, many greenhouse gas accounting systems allow some "passive" CO uptake, such as enhanced vegetation growth due to CO fertilisation, to be included as removals in the definition of net anthropogenic emissions.

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Introduction: We investigated the genetic determinants of variation in the hemoglobin glycation index (HGI), an emerging biomarker for the risk of diabetes complications.

Methods: We conducted a genome-wide association study (GWAS) for HGI in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial ( = 7,913) using linear regression and additive genotype encoding on variants with minor allele frequency greater than 3%. We conducted replication analyses of top findings in the Atherosclerosis Risk in Communities (ARIC) study with inverse variance-weighted meta-analysis.

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Article Synopsis
  • Microenvironmental factors play a key yet unclear role in the progression of soft tissue sarcomas, especially during their onset.
  • A novel zebrafish model was developed to differentiate among microenvironmental, precancerous, and cancer cells, focusing on malignant peripheral nerve sheath tumors (MPNST), which grow aggressively.
  • The study reveals that specific inflammatory signaling pathways are activated during the transition from precancerous to cancerous states, highlighting the role of macrophages and identifying periostin as a significant protein in MPNST progression.
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Background: The transition from medical student to emergency medicine resident is a critical point in training. Medical students start residency with different levels of understanding and some are not meeting the emergency medicine (EM) Level 1 milestones. Residency preparation courses (RPCs) were created to fill this gap and prepare medical students for residency.

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