Publications by authors named "J K Hon"

Transcatheter aortic valve implantation (TAVI) has been established as an effective treatment modality in patients with severe aortic stenosis (AS) and the uptake of TAVI is rapidly growing in the Asia-Pacific region. However, there exist a heterogeneity in the management of aortic stenosis and the use of TAVI among countries in the region. Reasons for these differences include anatomic variations, disparity in healthcare resources and infrastructure, and the lack of consensus on the optimal management of AS in the Asia-Pacific region.

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Guidelines recommend risk stratification of pulmonary arterial hypertension (PAH) patients to guide management. There are currently several risk stratification scores available, which have largely been validated in various pulmonary hypertension registries in the West but not in Asia. We aim to study the performance of these different risk scores in PAH patients from a multi-ethnic Asian population.

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  • The review analyzes how different infections in pregnant women affect their health, the baby’s development, and the placenta.
  • It discusses various types of infections (bacterial, viral, parasitic), their transmission, symptoms, and how they can be identified through placental examination.
  • The importance of early diagnosis and treatment is highlighted, as many infections can show no symptoms, and the placenta's role in protecting against these infections is also explored.
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  • The study investigates how specific microRNAs (miRNAs) affect progesterone resistance in endometriosis patients.
  • It analyzed samples from 18 control, eutopic, and ectopic groups using next-generation sequencing and qRT-PCR to assess miRNA and receptor expressions.
  • Key findings showed that certain miRNAs were upregulated in ectopic tissue and that ERα and ERβ expression levels varied, suggesting that miRNAs may contribute to progesterone resistance and could serve as potential biomarkers or therapeutic targets in endometriosis.
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