Using a Film of Digital Storytelling and Art to Decrease Stigma Toward Those With Substance Use Disorder.

The stigma associated with substance use disorder (SUD) harms the lives of people who use drugs (PWUD). Perceptions and projections such as PWUD are unclean, dangerous, noncompliant, or at fault for their addiction are unfounded and can harm the person's quality of life, impacting all social determinants of health. Stigmatic behaviors displayed in the healthcare setting directly influence the ability of the person with SUD to engage fully in their care as feelings of trust are replaced by shame.

A prospective multicenter validation of RETREAT for post-transplantation hepatocellular carcinoma recurrence prediction.

Background: The RETREAT score is a simple risk stratification tool for post-liver transplantation (LT) hepatocellular carcinoma (HCC) recurrence that has been validated in retrospective cohort studies. A prospective, multicenter study is needed to further demonstrate accuracy especially given evolving clinical demographics and HCC transplant practice.

Aim: To validate and compare the RETREAT score to other post-LT HCC recurrence risk scores in a contemporary, prospective cohort of patients.

Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7.

The ubiquitin-specific protease (USP) family of deubiquitinases (DUBs) are regulators of Ub signaling that share a common catalytic-domain fold. The dynamic nature of this domain is important for controlling the function of USPs, with inter- and intramolecular interactions often influencing the structure and enzymatic activity of these DUBs. This conformational flexibility, in combination with the high sequence conservation of the USP active site, has made it challenging to readily identify potent and selective inhibitors for individual USPs.

Agreement between extrapolated corneoscleral topographical data obtained during natural and retracted eyelid positions.

Purpose: To examine the influence of aperture size (corneoscleral data coverage) on extrapolated scleral sagittal height data generated by the Pentacam HR derived from the Corneo Scleral Profile (CSP) software, by comparing measurements obtained during natural and retracted eyelid positions.

Methods: Corneoscleral topography of the left eye of 20 young (age: 22 [3] years) healthy adults with normal corneas was measured using the Pentacam HR CSP with the eyelids in their natural primary gaze resting position and during eyelid retraction with a wire speculum. The measured and extrapolated sagittal height data were exported from the instrument and analysed over a range of chord diameters (10.

Using pupillometry to predict outcome in cognitive behavioral therapy for negative symptoms of schizophrenia.

Background: Clinical trials of cognitive-behavioral therapy (CBT) for negative symptoms of schizophrenia have provided mixed results, perhaps because some patients are more likely to benefit than others. Patients likely to benefit may be those with greater pre-treatment motivation. To better examine the effects of motivation on treatment outcome, more objective measures of motivation are needed.