Publications by authors named "J K Dhillon"
Article Synopsis
- Immunotherapy has enhanced survival rates for patients with advanced clear cell renal cell carcinoma (ccRCC), but many patients still develop resistance to treatment.
- A study examined tumor samples from patients with both treatment-naïve and treatment-exposed ccRCC, revealing that tumors exposed to immunotherapy contained more immune cells (like CD8+ T cells and neutrophils) and showed significant changes in cellular markers.
- Key findings included increased expression of COL4A1 and ITGAV in the stroma of treated tumors, suggesting a need for further investigation into how these changes impact the tumor immune environment and potential new therapies.
Senescent cells accumulate in aging tissues, impairing their ability to undergo repair and regeneration following injury. Previous research has demonstrated that targeting tissue senescence with senolytics can enhance tissue regeneration and repair by selectively eliminating SnCs in specific aged tissues. In this study, we focused on eliminating senescent skin cells in aged mice to assess the effects on subsequent wound healing.
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- * The disease is complex and involves immune responses where CD8+ T-cells target melanocytes, and various treatment strategies include phototherapy, grafting, and new drugs like JAK-STAT inhibitors.
- * Future research should focus on exploring alternative drug targets, genetic factors, and immune cell treatments, potentially leading to more effective and lasting solutions for vitiligo.
The advent of higher-quality imaging has brought increased attention to the understanding and implications of commonly observed hip morphology and pathology. Many patients and even physicians like to focus on the presence of an acetabular labral tear when one is present on magnetic resonance imaging, despite the limitations of magnetic resonance imaging in identifying labral tears. Furthermore, recent studies have shown normal variations of the acetabular labrum, as well as a high prevalence of labral tears in both symptomatic and asymptomatic individuals.
View Article and Find Full Text PDFPurpose: This study aimed to evaluate the humanistic burden of noninfectious uveitis (NIU).
Design: Systematic review and meta-analysis.
Methods: A comprehensive search was conducted across Medline, Embase, and Scopus databases from inception to March 2023.