Atypical Femur Fracture in a Teenager on Chronic Imatinib Therapy.

Atypical femoral fractures (AFFs) are rare fractures usually associated with medications that can ultimately alter bone metabolism. Imatinib, a drug prescribed for treatment of chronic myeloid leukemia (CML), has been associated with altered bone homeostasis, however, with unknown clinical significance. Here, we present the case of a 17-year-old female, with a diagnosis of CML undergoing chronic imatinib therapy, who developed an AFF treated successfully with prophylactic fixation with intramedullary nailing.

Social Determinants, Mental Well-Being, and Disrupted Life Transitions Among Young Adults with Disabling Mental Health Conditions.

This study sought to understand how young adults (age 18-25) with histories of mental health disorders are coping with disrupted transitions to adulthood during the COVID-19 pandemic. A cross-sectional web survey was conducted in March-June 2021 of 967 US young adults with pre-pandemic psychiatric disability to assess their current psychiatric status, interrupted transitions, and associations with social determinants including income, community participation, and social context. Mental health was assessed with the Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), and PTSD Checklist-Civilian Version.

Patient factors associated with treatment completion in a 12-week inpatient dual diagnosis treatment program.

Objective: To identify whether mental health wellbeing, age, gender or recent substance use pattern affected completion rates of a dual diagnosis inpatient program.

Method: This retrospective cohort study reviewed medical records of patients admitted between October 2018 and December 2021 of Westside Lodge, a dual diagnosis inpatient program. Demographic information, mental health screening tool results (BASIS-24) and self-reported substance use data were accessed from the patients' electronic medical records.

Investigating the presence of surgical learning in the Timing of Primary Surgery for cleft palate randomised trial.

Background/aims: When conducting a randomised controlled trial in surgery, it is important to consider surgical learning, where surgeons' familiarity with one, or both, of the interventions increases during the trial. If present, learning may compromise trial validity. We demonstrate a statistical investigation into surgical learning within a trial of cleft palate repair.