Publications by authors named "J K Chiu"
Gut microbial metabolism of L-carnitine, which leads to the production of detrimental trimethylamine N-oxide (TMAO), offers a plausible link between red meat consumption and cardiovascular risks. Several microbial genes, including , the operon, and the recently identified gene cluster, have been implicated in the conversion of dietary L-carnitine into TMA(O). However, the key microbial genes and associated gut microbes involved in this pathway have not been fully explored.
View Article and Find Full Text PDFPurpose: Treatment options for advanced head and neck squamous cell carcinoma (HNSCC) previously treated with platinum-based chemotherapy and a programmed death-1 (PD-1) inhibitor are limited. Trophoblast cell-surface antigen 2 (Trop-2) is highly expressed in HNSCC. Sacituzumab govitecan (SG) is a Trop-2-directed antibody-drug conjugate approved for patients with certain previously treated solid tumors.
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- LASIK surgery can cause temporary dry eye due to nerve damage, but this study investigates long-term ocular surface changes, blinking rates, and meibomian gland health in post-LASIK patients at least 48 months post-surgery.
- The study involved 48 post-LASIK patients and 48 matched healthy controls, assessing clinical findings and imaging related to eye health.
- Findings showed that post-LASIK patients had lower meibum quality, reduced tear production, and high chronic dry eye symptom prevalence, indicating the need for thorough evaluations and treatments for affected patients.
Alternative splicing of transcript mediates the response of circadian clocks to temperature changes.
Proc Natl Acad Sci U S A
December 2024
Circadian clocks respond to temperature changes over the calendar year, allowing organisms to adjust their daily biological rhythms to optimize health and fitness. In , seasonal adaptations are regulated by temperature-sensitive alternative splicing (AS) of () and () genes that encode key transcriptional repressors of clock gene expression. Although () gene encodes the critical activator of circadian gene expression, AS of its transcripts and its potential role in temperature regulation of clock function have not been explored.
View Article and Find Full Text PDFHungry animals consistently show a desire to obtain food. Even a brief sensory detection of food can trigger bursts of physiological and behavioral changes. However, the underlying mechanisms by which the sensation of food triggers the acute behavioral response remain elusive.
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