Publications by authors named "J K Candlish"

Article Synopsis
  • Next-generation ALK tyrosine kinase inhibitors (TKIs) like alectinib, brigatinib, and lorlatinib show better progression-free survival compared to chemotherapy or crizotinib for first-line treatment of ALK-positive advanced non-small cell lung cancer (NSCLC).
  • The study conducted a network meta-analysis (NMA) to compare the efficacy of lorlatinib with other ALK TKIs, focusing on progression-free survival and other outcomes, using data from ten trials.
  • Results indicated lorlatinib significantly improved progression-free survival compared to both alectinib and brigatinib, supporting its use as an effective first-line treatment for this type of lung cancer.
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The accessibility of the built environment is an equity issue. Accessibility standards for buildings exist, but often apply to new buildings or major renovations. This renders historic neighborhoods inaccessible.

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Background: Patient-reported outcome measures (PROMs) are now frequently used in randomised controlled trials (RCTs) as primary endpoints. RCTs are longitudinal, and many have a baseline (PRE) assessment of the outcome and one or more post-randomisation assessments of outcome (POST). With such pre-test post-test RCT designs there are several ways of estimating the sample size and analysing the outcome data: analysis of post-randomisation treatment means (POST); analysis of mean changes from pre- to post-randomisation (CHANGE); analysis of covariance (ANCOVA).

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Background: In proportionate or adaptive interventions, the dose or intensity can be adjusted based on individual need at predefined decision stages during the delivery of the intervention. The development of such interventions may require an evaluation of the effectiveness of the individual stages in addition to the whole intervention. However, evaluating individual stages of an intervention has various challenges, particularly the statistical design and analysis.

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