Publications by authors named "J K Akshay"
EGFR-TKIs have changed the landscape of metastatic NSCLC treatment with a significant improvement in survival of EGFRm patients compared to wild-type EGFR. Even with the newer third generation EGFR TKIs like, Osimertinib, which has proven efficacy against the resistance mutation of EGFRm T790M, progression eventually occurs. There are limited treatment options for patients with metastatic EGFRm NSCLC with other acquired resistance.
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- - The study investigated the anti-quorum sensing (AQS) and antibiofilm effects of ethyl acetate extracts from a Gram-negative bacterium associated with chronic human infections, specifically focusing on how these extracts affect acyl-homoserine lactone (AHL)-regulated molecules.
- - Researchers found that specific concentrations of the extracts significantly decreased violacein pigment production, AHL levels, exopolysaccharide (EPS) production, and biofilm formation compared to a control group.
- - Chemical analysis revealed that hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl) ethyl ester had the strongest interaction with the CviR protein, suggesting it could be a potential treatment option