Role of Ceftazidime-Avibactam in Urinary Tract Infections Caused by Carbapenem-Resistant Enterobacterales.

Introduction Urinary tract infections (UTIs) are one of the most common bacterial infections encountered in community and healthcare settings. Increasing antimicrobial resistance patterns worldwide have limited the treatment options available. Overuse of carbapenems which were considered as the last resort for multi-drug resistant UTIs over the past decade has led to the emergence of carbapenem-resistant Enterobacterales (CRE).

Second primary cancers: Incidence and outcomes from a population of patients accrued in six prospective controlled trials at a tertiary cancer institute.

Background: The aim of this study was to document the incidence, spectrum and outcomes of Second Primary Malignancy (SPM) in a prospectively followed-up population of Head and Neck Squamous carcinoma (HNSCC) patients accrued in six prospective trials and treated with definitive radiotherapy.

Materials And Methods: Patients were prospectively followed up over time and data on SPM collected after IRB approval after establishing the diagnosis of SPM based on clinical criteria. Descriptive statistics to determine clinic demographic characteristics and spectrum of SPM encountered, time to event outcomes (SPM-DFS - Disease-free survival after diagnosis of second primary, SPM-OS - Overall survival after diagnosis of second primary) and univariate analysis of factors of likely prognostic significance were performed.

Phenolic -OH-Induced Fluorescence and Chemoselectivity in a Triptycene-Based -Azo Oligomer for Sensing Applications.

A novel triptycene-based -azo fluorescent oligomer exhibiting phenolic groups has been designed. The presence of phenolic -OH in conjugation with the azo group rendered the oligomer fluorescence active by keto-enol tautomerism, which was evidenced by quenching the fluorescence intensity of in 1 M aq. NaOH.

Impact of Vaccination Time on Anti-SARS-CoV-2 Antibody Levels in Adults: A Quasi-experimental Study.

Background And Aim: Vaccination time may provide an opportunity to advance immunogenicity in terms of the immune system's circadian nature. This analytical study was planned to determine the impact of forenoon and afternoon administration of the COVID-19 vaccine to adults on the magnitude of antibody response.

Method: A total of 33 healthy adults with no history of COVID-19 infection or any other disease participated in the study.