Publications by authors named "J Jura"
The RNase activity of MCPIP1 is essential for regulating cellular homeostasis, proliferation, and tumorigenesis. Our study elucidates the effects of downregulation of MCPIP1 expression and an RNase-inactivating mutation (D141N) on normal epithelial kidney cells, indicating that MCPIP1 expression is a key factor that suppresses neoplastic transformation. We observed that either expression downregulation or mutation of MCPIP1 significantly increased its clonogenicity and altered the expression of cancer stem cell (CSC) markers and factors involved in epithelial-to-mesenchymal transition (EMT).
View Article and Find Full Text PDFSterile inflammation contributes to the development of many liver diseases including non-alcoholic fatty liver disease. Tumor necrosis factor alpha (TNFα) is a key cytokine driving liver inflammation primarily through pro-inflammatory activation of liver sinusoidal endothelial cells (LSEC). The knowledge of whether modulating LSEC activation can alleviate liver inflammation is scarce.
View Article and Find Full Text PDFThe challenge of enhancing wound healing and skin regeneration, particularly in conditions like burns and diabetic wounds, necessitates innovative solutions. Cholesterol, often associated with cardiovascular diseases, plays vital roles in cellular functions, maintaining skin integrity and preserving the skin barrier. Here, we explore cholesterol's significance, its influence on keratinocytes, and its potential application in skin regeneration.
View Article and Find Full Text PDFArticle Synopsis
- MCPIP1 is a protein that helps control inflammation and may prevent tumors; mice lacking this protein are more prone to developing skin tumors from certain chemical exposures.
- The study used advanced sequencing techniques to explore how MCPIP1 regulates specific microRNAs and their effect on gene expression in skin tumors induced by chemicals.
- Findings revealed significant changes in gene expression with 2400 different protein-coding genes and 33 microRNAs affected, highlighting the direct impact of MCPIP1 on microRNA levels and its role in promoting skin cancer cell growth.
Article Synopsis
- - The study analyzes the use of steel sludge and slag as substitutes for natural sand in cement mortars, addressing environmental concerns related to metallurgical waste from steel production and the potential leaching of harmful metal ions.
- - A Full Quadratic Response Surface Model (RSM) was used to assess the optimal replacement levels of sand with 0-20% of each waste type, revealing that while there are slight reductions in consistency and mechanical strength, mortars still show enhanced frost resistance and minimal environmental impact.
- - Incorporating a 40% mixture of sludge and slag allows significant sand conservation in mortar production, resulting in cost savings and promoting more sustainable construction practices, which is beneficial for a circular economy.