Publications by authors named "J Jungverdorben"
Article Synopsis
- Aging is a significant risk factor for Alzheimer's disease, and researchers conducted a whole-genome CRISPR screen to find out how neuronal age is regulated.
- They discovered that the neddylation pathway affects both cellular aging and neurodegeneration related to Alzheimer's in human stem cells.
- Blocking neddylation led to more signs of aging and neuron loss, suggesting that targeting this pathway could be a new strategy to slow down Alzheimer's progression.
Outer radial glia (oRG) emerge as cortical progenitor cells that support the development of an enlarged outer subventricular zone (oSVZ) and the expansion of the neocortex. The in vitro generation of oRG is essential to investigate the underlying mechanisms of human neocortical development and expansion. By activating the STAT3 signaling pathway using leukemia inhibitory factor (LIF), which is not expressed in guided cortical organoids, we define a cortical organoid differentiation method from human pluripotent stem cells (hPSCs) that recapitulates the expansion of a progenitor pool into the oSVZ.
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- - Mammalian outer radial glia (oRG) are crucial progenitor cells that help form the outer subventricular zone (oSVZ), which is important for the growth of the neocortex during brain development.
- - Researchers developed a new method to create cerebral organoids from human pluripotent stem cells that replicate the development of the oSVZ by activating the STAT3 pathway, which is absent in traditional models.
- - The presence of specific brain vascular cells producing LIF enhances the development of oRG in these organoids, highlighting how diverse cell types in the brain's microenvironment promote neural development and provide a platform for studying these processes.
The biological function and disease association of human endogenous retroviruses (HERVs) are largely elusive. HERV-K(HML-2) has been associated with neurotoxicity, but there is no clear understanding of its role or mechanistic basis. We addressed the physiological functions of HERV-K(HML-2) in neuronal differentiation using CRISPR engineering to activate or repress its expression levels in a human-pluripotent-stem-cell-based system.
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