Publications by authors named "J Joutsa"

Background And Objectives: Previous research has demonstrated increased brain amyloid plaque load in individuals with childhood-onset epilepsy in late middle age. However, the trajectory of this process is not yet known. The aim of this study was to determine whether individuals with a history of childhood-onset epilepsy show progressive brain aging in amyloid accumulation in late adulthood (Turku Adult Childhood-Onset Epilepsy study, TACOE).

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Background: While previous imaging studies have generally shown normal striatal dopamine transporter (DAT) binding in essential tremor (ET), emerging evidence suggests a partial dopaminergic mechanism in this condition and an epidemiological link between ET and Parkinson's disease (PD). This link seems particularly meaningful in ET patients with additional neurological signs, such as slowness of movements, rigidity, or rest tremor (ET+).

Objectives: To investigate the potential dopaminergic pathophysiology of ET+ and to compare it to PD.

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Word fluency (WF) tasks that tap verbal and executive function show deteriorating performance by advancing age. To address the scarcely studied age-related brain correlates of WF, we employed whole-brain voxel-based morphometry to examine gray matter (GM) correlates of semantic and phonemic WF in 46 healthy older adults. Lower phonemic WF score was related to smaller anterior medial temporal GM volume as well as smaller GM volume in the putamen bilaterally.

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Article Synopsis
  • A previous study found a specific brain network linked to cervical dystonia (CD), pointing out its potential for treatment, especially with non-invasive techniques like repetitive transcranial magnetic stimulation (rTMS).
  • The study aimed to evaluate how stimulating the somatosensory cortex (S1) affects brain metabolism in CD patients versus healthy controls, using methods like [F]FDG-PET to measure changes.
  • Results showed that cTBS significantly increased metabolism in the S1 and brainstem of CD patients, suggesting abnormal sensory function in CD and supporting future therapeutic trials using this stimulation method.
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