Publications by authors named "J Josko"
Background: Nowadays, shift work is a necessity. Unfortunately, according to many studies, it carries serious health implications, e.g.
View Article and Find Full Text PDFBackground: Intermittent clamping (IC) of the portal triad is an effective method of protecting the liver from ischemia-reperfusion injury (IR). In clinical practice, this method is employed during a resection, but its mechanism is still not clear.
Objectives: To evaluate the effect of IC on rat liver and determine its mechanisms.
As a first attempt at exploring an association between histaminergic and serotoninergic neuronal phenotypes in glucose regulation, the influence of the histamine H₃ receptor antagonist thioperamide on glucose uptake by brain was determined in rats in which the serotoninergic innervations of brain was largely destroyed perinatally. Male Wistar rats were initially treated on the 3rd day after birth with the serotoninergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) (75 μg icv) or saline vehicle (10 μl icv). At 8 weeks lesioned and control rats were terminated in order to validate the effectiveness of 5,7-DHT: reduction in 5-HT and 5-HIAA by 83-91% and 69-83% in striatum, frontal cortex, and hippocampus (HPLC/ED method).
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate the histamine content in the brains of adult rats that had been treated neonatally with a serotonin neurotoxin (5,7-DHT) and how histamine receptor antagonists affect their behavior.
- At 10 weeks old, the researchers measured serotonin levels and histamine levels in various brain regions using specific techniques, and they studied the rats' behaviors, including locomotion and exploration.
- The results indicated that serotonin levels were significantly reduced due to the neurotoxin treatment, which also led to decreased histamine content and altered behavioral responses to certain receptor antagonists, highlighting the relationship between the serotonin system and histamine receptor activity in influencing behavior.
Background: Quality of life is an important issue of public health. It becomes essential in the population of active workers, especially women who besides their occupational activity have to perform other important roles, such as care of their children or older parents.
Materials And Methods: The presented study is an attempt to answer the question on whether occupational activity, especially job satisfaction, provides better quality of live in the population of women aged 45-60 years.