Purpose Of Review: Peripheral neuropathy (PN) is more commonly seen in individuals with monoclonal gammopathies, especially in patients with an IgM monoclonal gammopathy or Waldenström macroglobulinemia.
Recent Findings: There are multiple potential ways that the paraprotein may result in peripheral neuropathy. The diagnosis and management of monoclonal gammopathy-associated PN are challenging and necessitate a concerted effort between the hematologist/oncologist and the neurologist.
Endoscopic gastric plication is an emerging procedure for obesity management, facilitated by advances in intraluminal suturing technology. However, concerns persist regarding the complete transfixion of sutures and their long-term durability. We present the case of a 28-year-old patient with a BMI of 31 kg/m² who underwent laparoscopic gastric plication using nonabsorbable sutures to ensure complete transfixion under direct visualization.
View Article and Find Full Text PDFLong-isolated subsurface brine environments (Ma-Ga residence times) may be habitable if they sustainably provide substrates, e.g. through water-rock reactions, that support microbial catabolic energy yields exceeding maintenance costs.
View Article and Find Full Text PDFAntimicrob Agents Chemother
December 2024
The clinical efficacy of combination drug regimens containing the first-generation diarylquinoline (DARQ) bedaquiline in the treatment of multidrug-resistant tuberculosis has validated ATP synthesis as a vulnerable pathway in . New DARQs in clinical development may be even more effective than bedaquiline, including against emerging bedaquiline-resistant strains. Telacebec (T) is a novel cytochrome bc:aa oxidase inhibitor that also inhibits ATP synthesis.
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