Publications by authors named "J Josh Castillo"

Purpose Of Review: Peripheral neuropathy (PN) is more commonly seen in individuals with monoclonal gammopathies, especially in patients with an IgM monoclonal gammopathy or Waldenström macroglobulinemia.

Recent Findings: There are multiple potential ways that the paraprotein may result in peripheral neuropathy. The diagnosis and management of monoclonal gammopathy-associated PN are challenging and necessitate a concerted effort between the hematologist/oncologist and the neurologist.

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Endoscopic gastric plication is an emerging procedure for obesity management, facilitated by advances in intraluminal suturing technology. However, concerns persist regarding the complete transfixion of sutures and their long-term durability. We present the case of a 28-year-old patient with a BMI of 31 kg/m² who underwent laparoscopic gastric plication using nonabsorbable sutures to ensure complete transfixion under direct visualization.

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Long-isolated subsurface brine environments (Ma-Ga residence times) may be habitable if they sustainably provide substrates, e.g. through water-rock reactions, that support microbial catabolic energy yields exceeding maintenance costs.

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The clinical efficacy of combination drug regimens containing the first-generation diarylquinoline (DARQ) bedaquiline in the treatment of multidrug-resistant tuberculosis has validated ATP synthesis as a vulnerable pathway in . New DARQs in clinical development may be even more effective than bedaquiline, including against emerging bedaquiline-resistant strains. Telacebec (T) is a novel cytochrome bc:aa oxidase inhibitor that also inhibits ATP synthesis.

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