Publications by authors named "J Jordan Shields"
Objective: Compare the effect of posterior surgical approach (PA) vs direct anterior approach (DAA) on speed of recovery from pain and dysfunction and on intrathecal oxytocin analgesia after total hip arthroplasty (THA).
Study Design: Nested cohort within a randomized, controlled, double-blind trial.
Setting: Hospital.
Background: The purpose of this study is to assess the short- and mid-term radiographic outcomes of a ream-then-broach metaphyseal cone design for revision total knee arthroplasty (rTKA).
Methods: A retrospective, multicenter analysis of rTKA patients utilizing femoral and/or tibial metaphyseal cone placement from January 2017 to July 2022 was performed. Assessment of radiolucency was performed utilizing a novel "cones score" for radiolucency for tibial and femoral cones.
Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the T cell receptor signaling pathway and is therefore a target of interest for immunooncology. Nonselective HPK1 inhibitors may affect other kinase components of T cell activation, blunting the beneficial impact of enhanced T cell activity that results from HPK1 inhibition itself. Here, we report the discovery of pyrazine carboxamide HPK1 inhibitors and their optimization through structure-based drug design to afford a highly selective HPK1 inhibitor, compound (AZ3246).
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- Cancer progression is heavily influenced by interactions within the tumor microenvironment (TME), especially involving immune cells that attempt to control tumor spread but often fail.
- Current preclinical models don’t effectively capture these complex interactions, limiting understanding of immune evasion and drug behavior.
- Biofabrication, specifically 3D bioprinting, shows promise for modeling tumors and immune interactions in vitro by incorporating various cell types, achieving spatial accuracy, and integrating blood vessels, though research in this area is still limited.
Purpose: To determine the impact of uveal melanoma thickness on patient survival from the date of presentation and at specific time intervals following metastasis-free survival.
Methods: In this retrospective cohort study, we evaluated data from 8034 consecutive uveal melanoma patients diagnosed at a tertiary care ocular oncology center between May 1972 and August 2007. The patients were categorized on the basis of tumor thickness (per each 1-mm increment) and evaluated for non-conditional survival (from date of presentation) and conditional survival (with 3-years, 5-years, and 10-years of metastasis-free survival) on the cumulative incidence of melanoma-related metastasis at 5-, 10-, 15-, 20-, 25- and 30-years.