Reducing time for vascular access salvage: initial results from a single institution's clinical practice improvement programme.

Background: One of the most common causes of arteriovenous fistula (AVF) and/or arteriovenous graft (AVG) failure is thrombosis. Guidelines recommend early AVF salvage within 24-48 hours. Our institution reported poor compliance with these recommendations, with a median of 3 days prior to vascular access (VA) salvage.

Comparison of human macrophages derived from peripheral blood and bone marrow.

Macrophage differentiation, phenotype, and function have been assessed extensively in vitro by predominantly deriving human macrophages from peripheral blood. It is accepted that there are differences between macrophages isolated from different human tissues; however, the importance of anatomical source for in vitro differentiation and characterization is less clear. Here, phenotype and function were evaluated between human macrophages derived from bone marrow or peripheral blood.

A variational deep-learning approach to modeling memory T cell dynamics.

Mechanistic models of dynamic, interacting cell populations have yielded many insights into the growth and resolution of immune responses. Historically these models have described the behavior of pre-defined cell types based on small numbers of phenotypic markers. The ubiquity of deep phenotyping therefore presents a new challenge; how do we confront tractable and interpretable mathematical models with high-dimensional data? To tackle this problem, we studied the development and persistence of lung-resident memory CD4 and CD8 T cells (T) in mice infected with influenza virus.

The future midwifery workforce: A survey of the education experiences of midwifery students in Australia.

Aim: To understand students' views on and experiences of their pre-registration midwifery education in Australia, including continuity of care experiences and clinical practice placements and their preferences for future employment.

Background: Increasing the number of midwifery student enrolments and improving student experience are suggested solutions to shortages in the Australian midwifery workforce.

Design: An anonymous online survey.

"Sometimes I'm interested in seeing a fuller story to tell with numbers" Implementing a forecasting dashboard for harm reduction and overdose prevention: a qualitative assessment.

Objectives: The escalating overdose crisis in the United States points to the urgent need for new and novel data tools. Overdose data tools are growing in popularity but still face timely delays in surveillance data availability, lack of completeness, and wide variability in quality by region. As such, we need innovative tools to identify and prioritize emerging and high-need areas.