Publications by authors named "J Joly"
Article Synopsis
- Dynamic covalent bonding (DCB) is gaining attention in materials science for its potential in drug development targeting tropical parasitic diseases like malaria and bilharziasis.
- Recent findings indicate that certain alkoxyamines, which showcase DCB, demonstrate significant effectiveness against these parasites, achieving 100% mortality in worms and specific inhibitory concentrations.
- The research utilizes both enzymatic-physical and enzymatic-chemical activation methods to enhance the efficacy of alkoxyamines, with the enzymatic component ensuring targeted drug action.
Article Synopsis
- The study explored whether smartphone applications could help individuals manage rheumatoid arthritis (RA) by assessing their engagement and any negative psychological impacts.
- Conducted as a multicentre randomized controlled trial, 122 participants were assigned to either usual care or one of two app-based self-management interventions, focusing on patient education, goal-setting, and remote monitoring over 16 weeks.
- Results showed no significant improvement in self-efficacy compared to usual care, but the remote monitoring did not increase pain catastrophizing, suggesting the psychological impact of app use is minimal.
Objective: To discover antibody biomarkers that can predict a lack of response to first-line therapy in rheumatoid arthritis (RA) patients.
Methods: Two RA cDNA phage display libraries were screened for novel antibodies in baseline RA sera from the Care in early RA (CareRA) trial, differentiating between patients who did or did not reach remission after first-line therapy (n=20 each). Antibody reactivity to identified University Hasselt (UH)-RA antigens was validated in baseline samples from 136 additional CareRA participants.
Melatonin (MLT) is a hormone that can stimulate bone formation and inhibit bone resorption, among other functions. Aim: To evaluate the effect on new bone formation of MLT applied locally to critical defects created in the calvaria of rats, compared to the effect of Bio-Oss® xenogeneic bone substitute (BO), by analyzing histomorphometry, microtomography and gene expression. Materials and Method: Two critical defects (5.
View Article and Find Full Text PDFBackground: The optimal retreatment strategy with rituximab for rheumatoid arthritis (RA) remains a point of discussion. Depending on local guidelines, rituximab can either be administered at fixed intervals or when losing disease control, balancing therapeutic effectiveness with drug overexposure. However, treatment based on loss of disease control may significantly affect patients' lives, provoking uncertainty and potentially leading to progressive joint damage.
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