Publications by authors named "J Joerns"
The formation of antibodies against donor human leukocyte antigens poses a challenging problem both for donor selection as well as postoperative graft function in lung transplantation. These donor-specific antibodies limit the pool of potential donor organs and are associated with episodes of antibody-mediated rejection, chronic lung allograft dysfunction, and increased mortality. Optimal management strategies for clearance of DSAs are poorly defined and vary greatly by institution; most of the data supporting any particular strategy is limited to small-scale retrospective cohort studies.
View Article and Find Full Text PDFBackground: COVID patients continue to experience unremitting symptoms that extend far beyond the initial illness. While there is rapid accumulation of data on acute COVID treatment in hospitalized patients, little is known regarding post-COVID management.
Objectives: To describe our center's experience treating post-COVID sub-syndromes encountered in Post-COVID Lung Clinic.
The presence of a certain group of auto-antibodies (AAbs) is known to correlate with the severity of COVID-19. It is, however, unknown if such AAbs are prevalent and impact COVID-19-related outcomes in lung transplant recipients (LTRs) who are immunosuppressed. We performed a retrospective study of LTRs with COVID-19 and analyzed samples before and after COVID-19 for IgG AAbs.
View Article and Find Full Text PDFEpidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury.
Oxid Med Cell Longev
October 2022
Article Synopsis
- This study explored how inhibiting the epidermal growth factor receptor (EGFR) affects lung injury caused by severe hyperoxia (high oxygen levels over 95%).
- Researchers found that mice with inhibited EGFR had better survival rates and less lung injury compared to normal mice when exposed to 100% oxygen.
- The study highlights that blocking EGFR reduces cell death in lung cells, suggesting it plays a protective role against hyperoxia-induced lung damage, and calls for further investigation into this process.
Article Synopsis
- * The clinical symptoms associated with the Omicron infection were more severe compared to the Delta infection, raising concerns about its impact on lung transplant patients.
- * The study calls for further investigation into the effects of new COVID-19 variants on lung transplant patients and suggests keeping a cautious approach until more data is available.