Melanin formation in the inner ear is catalyzed by a new tyrosine hydroxylase kinetically and structurally different from tyrosinase.

Detergent solubilized extracts of the cochleae of adult gerbils (Meriones unguiculatus) contain a tyrosine hydroxylase activity measurable by the radiometric method of Pomerantz. This activity is not related to Fenton-type reactions, since it is not inhibited by free radical scavengers and is heat and protease sensitive. It does not appear to be related to a peroxidase (EC 1.

[Laryngeal cancer and secondary neoplasms in Murcia].

A retrospective study was made of 428 patients who underwent faryngectomy for cancer of the larynx. Tumor-dependent factors, treatment, and postoperative evolution were analyzed. Total laryngectomy was performed in 74% of cases.

[Laryngeal cancer in Murcia].

A retrospective study was made of a sample of 428 patients with laryngectomy for cancer of the larynx. We analyzed host-dependent factors, personal and familial antecedents, duration of evolution, symptoms, neoplasm site and TNM. Mean age was 60 years.

[Cancer of the larynx and 5 years survival].

Between the years 1971 and 1984, 428 patients with the diagnosis of laryngeal carcinoma were operated at the ENT Department of Virgen de la Arrixaca Hospital (Murcia, Spain). All of them submited to laryngectomy. The 5-years actuarial recurrence-free rate and its correlations with host factor are studied.

[Cancer of the larynx and discriminant analysis].

In order to get the prognosis on the 5 years survival, free of disease, in a sample of 428 laryngectomies, for cancer of the larynx, the AA. have realized a discriminant analysis working out with several known factors. Only from 109 components of the group complete information could be available about the variables studied and with these a linear discriminant function was obtained.