Publications by authors named "J Jeffrey McCullough"
Background: In critically ill patients with acute kidney injury (AKI), a fluid balance (FB) > 2 L at 72 h after AKI diagnosis is associated with adverse outcomes. Identification of patients at high-risk for such fluid accumulation may help prevent it.
Methods: We used Australian electronic medical record (EMR)-based clinical data to develop the "AKI-FB risk score", validated it in a British cohort and used it to predict a positive FB >2 L at 72 h after AKI diagnosis.
Objective: The optimal timing of vasopressin initiation as an adjunctive vasopressor remains unclear. We aimed to study the association between the timing of vasopressin commencement, pre-specified physiological parameters, and hospital mortality.
Design: We conducted a multicentre, retrospective, observational study.
Objective: Knowledge of intensive care unit (ICU) acquired hypernatremia (ICU-AH) has been hampered by the absence of granular data and confounded by variable definitions and inclusion criteria.
Design: Multicentre retrospective cohort study.
Setting: Twelve ICUs in Queensland (QLD), Australia.
Article Synopsis
- The paradox of the great speciators describes a conflicting pattern in avian lineages in Oceania that shows broad geographic distributions indicative of strong dispersal, yet also displays significant genetic divergence suggesting limited inter-island movement.
- A study using genomic sequencing of dwarf kingfishers from northern Melanesia found deep genetic divergence and an absence of gene flow between nearby island populations, highlighting the paradox effectively.
- The research proposes a framework based on founder effects and changing selection pressures that explains how diverse traits and environmental factors influence dispersal capabilities, shedding light on the evolutionary dynamics of these bird lineages.
rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination.
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