Micro-doping tin-bismuth on modification of CoO electrocatalyst and degradation of ammonia nitrogen.

CoO has exhibited chlorine evolution reaction (CER) activity comparable to that of RuO. However, it is plagued by relatively low catalytic activity and insufficient long-term stability. In the field of cobalt oxide doping, typically, a relatively large quantity of dopants is used to modulate its performance.

Genetic and epigenetic mechanisms of GPRC5D loss after anti-GPRC5D CAR T-cell therapy in multiple myeloma.

G protein-coupled receptor, class C, group 5, member D (GPRC5D) has emerged as a novel target for chimeric antigen receptor (CAR) T-cell therapy, demonstrating promising efficacy in multiple myeloma (MM). However, disease relapse is still common, and the mechanism of resistance remains poorly understood. In this study, we conducted whole-genome sequencing (WGS) and whole-genome bisulfite sequencing (WGBS) on MM samples from 10 patients who relapsed after GPRC5D CAR T-cell therapy.

Decoding genetic diversity through genome engineering in bryophytes.

Bryophytes, which include mosses, liverworts, and hornworts, have evolved a highly successful strategy for thriving in terrestrial environments, allowing them to occupy nearly every land ecosystem. Their success is due to a unique combination of biochemical adaptations, diverse structural forms, and specialized life cycle strategies. The key to their evolutionary success lies in their genomic diversity.

Lateral habenula induces cognitive and affective dysfunctions in mice with neuropathic pain via an indirect pathway to the ventral tegmental area.

Neuropathic pain, which has become a major public health concern, is frequently accompanied by the deterioration of affective behavior and cognitive function. However, the brain circuitry underlying these changes is poorly understood. Therefore, we aimed to identify in a mouse model the converging circuit that influences the sensory, affective, and cognitive consequences of neuropathic pain.

Broad complex negatively regulates Fibrohexamerin/P25 by binding to the cis-element BMFA in the silkworm, Bombyx mori.

Silk proteins, as natural macromolecular substances, hold significant potential for applications in biomaterials and biomedical fields. The expression of silk protein genes exhibits spatiotemporal specificity. Broad Complex (BrC), a key primary response factor to 20-hydroxyecdysone, plays a crucial role in metamorphosis.