Publications by authors named "J Jakucs"
Article Synopsis
- The Linearbandkeramik (LBK) Neolithic communities were pioneers in spreading agriculture across Europe and this study showcases genetic data from 250 individuals to understand their ancestry.
- The findings reveal a notable difference in ancestry, with eastern LBK sites having a higher percentage of western hunter-gatherer genetics compared to western sites, indicating separate genetic paths for these groups.
- Additionally, the research suggests a patrilocal social structure, featuring more genetic connections among males within sites, and points out that the massacre at Asparn-Schletz likely involved individuals from a large population rather than a small community.
During the sixth millennium BCE, the first farmers of Central Europe rapidly expanded across a varied mosaic of forested environments. Such environments would have offered important sources of mineral-rich animal feed and shelter, prompting the question: to what extent did early farmers exploit forests to raise their herds? Here, to resolve this, we have assembled multi-regional datasets, comprising bulk and compound-specific stable isotope values from zooarchaeological remains and pottery, and conducted cross-correlation analyses within a palaeo-environmental framework. Our findings reveal a diversity of pasturing strategies for cattle employed by early farmers, with a notable emphasis on intensive utilization of forests for grazing and seasonal foddering in some regions.
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- TP53 mutations are linked to chemoresistance in chronic lymphocytic leukaemia (CLL) and can indicate the ineffectiveness of standard chemoimmunotherapy, prompting a need for better mutation assessment.* -
- In a study of 901 CLL patients, 17.5% had TP53 mutations, with nearly half being low-burden mutations, which raises questions about their clinical significance.* -
- Low-burden TP53 mutations led to earlier treatment initiation compared to patients without mutations, suggesting the need to reconsider the detection threshold for these mutations in diagnostics.*
Article Synopsis
- Lactase persistence (LP) evolved as a significant genetic trait in European, African, Middle Eastern, and South Asian populations over the last 10,000 years, largely influenced by milk consumption patterns.
- Despite evidence of widespread milk use in Europe since the Neolithic period, the relationship between prehistoric milk consumption and LP allele frequency is complex and suggests that other factors, such as environmental stressors, may have played a role in driving LP selection.
- The findings indicate that LP's rise in frequency may be better understood in the context of population dynamics and challenges faced by societies, rather than solely through the lens of milk exploitation.