Effects of two antihypertensive agents on lipids, lipoproteins, and apoproteins A and B. Comparison of prazosin and atenolol.

To compare the effects of prazosin and atenolol on plasma lipid concentrations, 60 patients with arterial hypertension (diastolic 90 to 120 mm Hg, systolic 160 to 200 mm Hg) were allocated at random to one of two treatment groups. The lipid profile included the determination of total cholesterol and triglyceride levels by ultracentrifugation, and assays of apoproteins A1 and B by laser immunonephelometry. Determinations were performed 30 days before and on the first, 90th, and 180th days of treatment.

[Comparative study of the effects of prazosin and atenolol on plasma lipids of hypertensive patients].

In order to investigate comparatively the effects of prazosin and atenolol on plasma lipid concentrations, 60 patients from two centres, presenting with arterial hypertension (diastolic 90-120 mmHg, systolic 160-200 mmHg), were allocated at random to one or the other of these drugs. The lipid profile, stable during the period of observation, included total cholesterol and triglycerides, study by ultracentrifugation, and assays of apoproteins A1 and B by laser immunonephelometry. Determinations were performed 30 days before, and on the 1st, 90 th and 180 th days of treatment.

Type IIa hyperlipoproteinemia and HLA-A and B antigens: no association.

One hundred unrelated patients with type IIa hyperlipoproteinemia have been investigated for their HLA-A and B antigens and compared to 171 normal controls. This study does not support the significant increase of HLA-B17 and Bw35 previously reported by others.

Comparative effects of prazosin and atenolol on plasma lipids in hypertensive patients.

Adverse modifications of blood lipid fractions are thought to be an additional risk factor in hypertensive patients treated with some antihypertensive drugs. The purpose of this study was to compare the changes in concentrations of lipid fractions in patients treated with either the cardioselective beta blocker atenolol or the selective alpha 1 blocker prazosin. When used in approximately equipotent doses for antihypertensive effect, prazosin and atenolol demonstrated different effects on lipid metabolism.