Publications by authors named "J J den Otter"
Article Synopsis
- Carbapenemase-producing Enterobacterales (CPE), particularly those encoding imipenemase (IMP), were studied for their emergence in a London healthcare network from 2016-2019, showcasing major antibiotic resistance issues across various species.
- The research combined network analysis of patient pathways with genomic studies, identifying 84 Enterobacterales isolates, mainly from Klebsiella, Enterobacter, and E. coli, with a high prevalence of a specific plasmid linked to resistance genes.
- Findings revealed an unnoticed interspecies outbreak through plasmid sharing, emphasizing the need for enhanced investigation techniques like DNA sequencing to effectively track and manage pathogen transmission in hospital settings.
Background: Hospital drains and water interfaces are implicated in nosocomial transmission of pathogens. Metagenomics can assess the microbial composition and presence of antimicrobial resistance genes in drains ('the drainome') but studies applying these methods longitudinally and to assess infection control interventions are lacking.
Aim: To apply long-read metagenomics coupled with microbiological measurements to investigate the drainome and assess the effects of a peracetic-acid-containing decontamination product.
The periphery of the hospital water system interfaces at multiple points with patients and staff in clinical areas. This comprises mostly sinks and showers and presents a significant infection control risk. Wastewater drains in particular act as a reservoir of pathogens that can be transmitted to patients.
View Article and Find Full Text PDFBackground: The role of the healthcare environment in the transmission of clinical pathogens is well established. EN 17126:2018 was developed to address the need for regulated sporicidal product testing and includes a realistic medical soil to enable validation of products that claim combined cleaning and disinfection efficacy.
Aim: To investigate the chemical stability and sporicidal efficacy of oxidizing disinfectant products in the presence of simulated clean and medical dirty conditions.