Publications by authors named "J J de Goeij"
Background And Aims: Familial hypercholesterolemia (FH) is a highly prevalent genetic disorder resulting in markedly elevated LDL cholesterol levels and premature coronary artery disease. FH underdiagnosis and undertreatment require novel detection methods. This study evaluated the effectiveness of using an LDL cholesterol cut-off ≥99.
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- - The study investigates the knowledge and practice of familial hypercholesterolaemia (FH) care among Dutch general practitioners (GPs) to address underdiagnosis and undertreatment of the condition, which can lead to early cardiovascular disease.
- - An online questionnaire revealed that while a majority of GPs rated their familiarity with FH positively, many lacked accurate understanding of key FH concepts, with 58.4% scoring low on knowledge questions.
- - Findings show that despite better familiarity and guideline awareness in the Netherlands compared to other regions, significant knowledge gaps remain, highlighting the need for improved education and global collaboration in FH understanding.
Article Synopsis
- This study investigates familial hypercholesterolaemia (FH) patients, focusing on their lifetime exposure to low density lipoprotein cholesterol (LDL-C) and its impact on subclinical atherosclerosis and coronary health.
- Researchers compared genetically diagnosed FH patients to a control group using coronary CT angiography and found that FH patients had significantly higher LDL-C exposure and more coronary plaque.
- The findings suggest that early and aggressive lipid-lowering therapy is essential in reducing coronary plaque burden in FH patients, highlighting the value of periodic monitoring to tailor treatment strategies.
The increased release of dissolved organic matter (DOM) by algae has been associated with the fast but inefficient growth of opportunistic microbial pathogens and the ongoing degradation of coral reefs. Turf algae (consortia of microalgae and macroalgae commonly including cyanobacteria) dominate benthic communities on many reefs worldwide. Opposite to other reef algae that predominantly release DOM during the day, turf algae containing cyanobacteria may additionally release large amounts of DOM at night.
View Article and Find Full Text PDFBackground: Sponge holobionts (i.e., the host and its associated microbiota) play a key role in the cycling of dissolved organic matter (DOM) in marine ecosystems.
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