cGAN-assisted imaging through stationary scattering media.

Analyzing images taken through scattering media is challenging, owing to speckle decorrelations from perturbations in the media. For in-line imaging modalities, which are appealing because they are compact, require no moving parts, and are robust, negating the effects of such scattering becomes particularly challenging. Here we explore the use of conditional generative adversarial networks (cGANs) to mitigate the effects of the additional scatterers in in-line geometries, including digital holographic microscopy.

Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening.

A virtual screen of a subsection of the AstraZeneca compound collection was performed for checkpoint kinase-1 (Chk-1 kinase) using a knowledge-based strategy. This involved initial filtering of the compound collection by application of generic physical properties followed by removal of compounds with undesirable chemical functionality. Subsequently, a 3-D pharmacophore screen for compounds with kinase binding motifs was applied.

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases.

The discovery of various protein/receptor targets from genomic research is expanding rapidly. Along with the automation of organic synthesis and biochemical screening, this is bringing a major change in the whole field of drug discovery research. In the traditional drug discovery process, the industry tests compounds in the thousands.

The reconstruction of a spatially incoherent two-dimensional source in an acoustically rigid rectangular cavity.

This paper applies Green's function modal expansion techniques to inverse source problems within an acoustically rigid rectangular cavity. In particular, solutions are developed for the reconstruction of a random spatially incoherent distributed source and a deterministic point source by using pressure-field measurements on adjacent walls. Such problems have seemingly not been addressed previously.