Publications by authors named "J J WEINER"

With the recent rise in the rate of alcohol use disorder (AUD) in women, the historical gap between men and women living with this condition is narrowing. While there are many commonalities in how men and women are impacted by AUD, an accumulating body of evidence is revealing sex-dependent adaptations that may require distinct therapeutic approaches. Preclinical rodent studies are beginning to shed light on sex differences in the effects of chronic alcohol exposure on synaptic activity in a number of brain regions.

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Article Synopsis
  • Cardiomyopathy is a major cause of death in boys with Duchenne muscular dystrophy (DMD), and this study investigates cardiac function using cardiac magnetic resonance (CMR) imaging to compare DMD patients with healthy controls.
  • The study involved 179 DMD patients and 96 healthy controls, focusing on measuring left ventricular (LV) function, with findings demonstrating significant differences in ventricular volumes and ejection rates, indicating compromised cardiac function in DMD patients.
  • Results suggest that certain CMR filling and ejection indices correlate with increased mortality in DMD patients, highlighting the potential for these measures to serve as important prognostic tools.
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The significance of thyroid hormones (THs) in beige adipocyte thermogenesis remains incompletely understood. We previously reported that THs directly regulate the expression of zinc-finger protein 423 (ZFP423), an anti-thermogenic factor, in adipose tissue. This study investigates the interaction between THs and adrenergic signaling in regulating thermogenic capacity and activation of beige adipocytes formed in response to Zfp423 deletion.

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