Tracheal Transplantation.

Airway stenosis and malignant tumors are the 2 main reasons to perform a surgical resection of part of the trachea. Tracheal lesions with a length shorter than 5 cm can be resected and primary reconstruction can be safely effected. Excessive anastomotic tension should be avoided because it may lead to restenosis or dehiscence at the anastomosis.

Protection of stromal cell-derived factor-1 SDF-1/CXCL12 against proteases yields improved skin wound healing.

SDF-1/CXCL12 is a unique chemotactic factor with multiple functions on various types of precursor cells, all carrying the cognate receptor CXCR4. Whereas individual biological functions of SDF-1/CXCL12 have been well documented, practical applications in medicine are insufficiently studied. This is explained by the complex multifunctional biology of SDF-1 with systemic and local effects, critical dependence of SDF-1 activity on aminoterminal proteolytic processing and limited knowledge of applicable modulators of its activity.

Treatment and outcome of fracture-related infection of the clavicle.

Introduction: The number of operatively treated clavicle fractures has increased over the past decades. Consequently, this has led to an increase in secondary procedures required to treat complications such as fracture-related infection (FRI). The primary objective of this study was to assess the clinical and functional outcome of patients treated for FRI of the clavicle.

Physiological fibrin hydrogel modulates immune cells and molecules and accelerates mouse skin wound healing.

Introduction: Wound healing is a complex process to restore homeostasis after injury and insufficient skin wound healing is a considerable problem in medicine. Whereas many attempts of regenerative medicine have been made for wound healing with growth factors and cell therapies, simple pharmacological and immunological studies are lagging behind. We investigated how fibrin hydrogels modulate immune cells and molecules in skin wound healing in mice.