Publications by authors named "J J Theunissen"
Magnetic seed localization is a novel and reliable technique for perioperative localization of non-palpable breast cancers. However, due to susceptibility artifacts, magnetic seeds cannot be during response monitoring of neoadjuvant chemotherapy with MRI. Contrast-enhanced mammography (CEM) could provide an alternative modality for response monitoring while magnetic seeds are .
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- Tissue factor (TF) is commonly overexpressed in various cancers and is linked to worse outcomes, making it a target for treatment using the anti-TF antibody-drug conjugate XB002.
- XB002 effectively delivers a cytotoxic agent specifically to TF-expressing tumors while avoiding unintended side effects such as bleeding, as shown by its ability to not disrupt coagulation pathways.
- In preclinical studies, XB002 demonstrated strong anti-tumor effects in multiple cancer types, leading to complete tumor regression in some models, and showed promising safety profiles in non-human primates, supporting further clinical development.
Since its introduction in 2012, contrast-enhanced mammography (CEM) has shown increased clinical relevance as a diagnostic tool in breast imaging. Its diagnostic accuracy is on par with breast MRI, rendering it a viable and potentially cost-effective alternative for breast MRI indications, especially in areas with lower accessibility to MRI. Like MRI, CEM occasionally shows 'CEM-only' lesions, i.
View Article and Find Full Text PDFBackground: Key populations (KP), including men who have sex with men (MSM), female sex workers (FSW), and transgender women (TGW), experience a disproportionate burden of HIV, even in generalized epidemics like South Africa. Given this disproportionate burden and unique barriers to accessing health services, sustained provision of care is particularly relevant. It is unclear how the COVID-19 pandemic and its associated restrictions may have impacted this delivery.
View Article and Find Full Text PDFPurpose: This study aimed to assess the incidence of plate-related complications and the need for plate removal after volar plate osteosynthesis of the distal radius in relation to Soong classification.
Methods: All consecutive patients (age > 16 years) in our level II trauma center treated with plate osteosynthesis for distal radius fractures from January 2017 until June 2019 were retrospectively evaluated. The main outcome measures were volar plate positioning according to Soong classification and incidence of plate removal.