Publications by authors named "J J Sobotka"

Stress-strain curves are generally a very important material characteristic. For example, in numerical simulations, especially in sheet metal forming, stress-strain curves represent one of the most important data inputs. However, there is quite a wide range of parameters that influence their outline under the chosen technological conditions and, therefore, must always be taken into account.

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Polycyclic aromatic hydrocarbons (PAHs), released from petrogenic, pyrogenic or diagenetic sources (degradation of wood materials), are of global concern due to their adverse effects, and potential for long-range transport. While dissolved PAHs have been frequently reported in the literature, there has been no consistent approach of sampling across water bodies. Passive samplers from the AQUA/GAPS-MONET initiative were deployed at 46 sites (28 marine and 18 freshwater), and analyzed for 28 PAHs and six polycyclic musks (PCMs) centrally.

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This paper deals with the analysis of TRIP steel HCT690 deformation behaviour. The mechanical properties and deformation characteristics of the tested material are determined using selected material tests and tests that consider the required stress states used to define the yield criterion boundary condition and subsequent deformation behaviour in the region of severe plastic deformation. The measured data are subsequently implemented in the numerical simulation of sheet metal forming, where they are used as input data for the computational process in the form of a selected material model defining the yield criterion boundary and, furthermore, the material hardening law during deformation of the material.

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Article Synopsis
  • People with Li-Fraumeni syndrome (LFS) have a near 100% chance of developing cancer due to a mutation in the TP53 gene and undergo regular cancer screening.
  • A new liquid biopsy test combining various sequencing techniques was tested on 89 LFS patients, showing improved cancer detection rates compared to traditional methods.
  • This integrated testing approach demonstrated earlier detection of cancer signals, highlighting its potential as a valuable tool in patient care, although further validation is needed before widespread use.
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  • At least 5% of cancer diagnoses are linked to hereditary cancer syndromes (HCS), leading to lifelong monitoring and anxiety for those affected.
  • The CHARM Consortium was established in 2017 by genetics centers in Canada to explore the clinical validity of cell-free DNA (cfDNA) sequencing as a non-invasive cancer monitoring method for individuals with HCS.
  • The consortium aims to shift cancer surveillance strategies towards more accessible and frequent monitoring, leveraging early detection opportunities identified through their research on commonly characterized HCSs like hereditary breast and ovarian cancer and Lynch syndrome.
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