Development, Measurement Properties and Reference Values of the Upper Extremity Motor Coordination Test: A New Motor Coordination Test of the Upper Limbs.

Background And Purpose: To develop a new test to assess the motor coordination of the upper limbs, and to investigate the test-retest and inter-rater reliability, construct validity, standard error of measurement (SEM), minimum detectable change (MDC), and the reference values.

Methods: The Upper Extremity Motor Coordination Test (UEMOCOT)was applied for 20 s, with the individual touching two targets (one right and one left) as quickly as possible, first with the hand (manual task) and then with the index finger (finger task). To test-retest reliability, the UEMOCOT was administered two times.

A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson's Disease.

In Parkinson's disease, dopaminergic neurons (DANs) in the midbrain gradually degenerate, with ventral substantia nigra pars compacta (SNc) DANs exhibiting greater vulnerability. However, it remains unclear whether specific molecular subtypes of ventral SNc DANs are more susceptible to degeneration in PD, and if they contribute to the early motor symptoms associated with the disease. We identified a subtype of Sox6+ DANs, Anxa1+, which are selectively lost earlier than other DANs, and with a time course that aligns with the development of motor symptoms in MitoPark mice.

Histological and stereological insights into renal and adrenal changes in pregnant rats exposed to wood smoke-derived PM2.5.

Air pollution, particularly fine particulate matter (PM2.5), is a global health issue affecting millions. In southern Chile, firewood used for heating exacerbates pollution, especially in winter.

Breast cancer patterns by age groups in Brazil: insights from population-based registries data.

Background: Breast cancer (BC) has exhibited varied epidemiological trends based on distinct age categories. This research aimed to explore the incidence and mortality rates of BC within pre-defined age groups in the Brazilian population.

Methods: BC incidence trends were assessed from 2010 to 2015 using Brazilian Population-Based Cancer Registries, employing age-standardized ratios and annual average percentage change (AAPC).

Development and Testing of an Objective Structured Clinical Examination for Evaluating Nurses in Infusion Therapy.

This study aimed to develop, assess, and test an Objective Structured Clinical Examination (OSCE) to evaluate nurses' competency in planning and managing infusion therapy. The study adopted a methodological approach with a quantitative design and was conducted from December 2020 to August 2021 at a university hospital in São Paulo, Brazil. Data collection occurred in 3 stages: development of scenarios and assessment checklists, evaluation of expert consensus, and testing scenarios with the target audience.